Renin gene haplotype diversity and linkage disequilibrium in two Mexican and one German population samples

@article{ValdezVlzquez2011ReninGH,
  title={Renin gene haplotype diversity and linkage disequilibrium in two Mexican and one German population samples},
  author={L. L. Valdez-V{\'e}l{\'a}zquez and F. Mendoza-Carrera and Sandra A Perez-Parra and Katia Rodarte-Hurtado and L. Sandoval-Ram{\'i}rez and H. Montoya-Fuentes and A. Quintero-Ramos and I. Delgado-Enciso and Daniel A. Montes-Galindo and Z. G{\'o}mez-Sandoval and N. Olivares and F. Rivas},
  journal={Journal of the Renin-Angiotensin-Aldosterone System},
  year={2011},
  volume={12},
  pages={231 - 237}
}
Introduction. Renin is the main rate-limiting enzyme in the renin—angiotensin—aldosterone system. Its gene, REN, is a candidate crucial factor in essential hypertension and cardiovascular disease. The aim of this study was to evaluate allele and haplotype distributions of REN polymorphisms, and to estimate normalised linkage disequilibrium (D’) in Mexican and German populations. Materials and methods. Four groups were studied for the REN single nucleotide polymorphisms (SNPs) 1205C>T, 1303G>A… Expand

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