Renin-angiotensin system transgenic mouse model recapitulates pathophysiology similar to human preeclampsia with renal injury that may be mediated through VEGF.

@article{Denney2017ReninangiotensinST,
  title={Renin-angiotensin system transgenic mouse model recapitulates pathophysiology similar to human preeclampsia with renal injury that may be mediated through VEGF.},
  author={J Morgan Denney and Cynthia E Bird and Annette P Gendron-Fitzpatrick and Emmanuel Sampene and Ian M. Bird and Dinesh M. Shah},
  journal={American journal of physiology. Renal physiology},
  year={2017},
  volume={312 3},
  pages={
          F445-F455
        }
}
Using a transgenic cross, we evaluated features of preeclampsia, renal injury and the sFlt1/VEGF changes. Transgenic hAGT and hREN, or wild-type (WT) C57Bl/6 mice were cross-bred: female hAGT × male hREN for preeclampsia (PRE) model and female WT × male WT for pregnant controls (WTP). Samples were collected for plasma VEGF, sFlt1, and urine albumin. Blood pressures (BP) were monitored by telemetry. Vascular reactivity was investigated by wire myography. Kidneys and placenta were immunostained… CONTINUE READING