Renin-angiotensin system in vertebrates: phylogenetic view of structure and function.

@article{Nishimura2017ReninangiotensinSI,
  title={Renin-angiotensin system in vertebrates: phylogenetic view of structure and function.},
  author={Hiroko Nishimura},
  journal={Anatomical science international},
  year={2017},
  volume={92 2},
  pages={215-247}
}
Renin substrate, biological renin activity, and/or renin-secreting cells in kidneys evolved at an early stage of vertebrate phylogeny. Angiotensin (Ang) I and II molecules have been identified biochemically in representative species of all vertebrate classes, although variation occurs in amino acids at positions 1, 5, and 9 of Ang I. Variations have also evolved in amino acid positions 3 and 4 in some cartilaginous fish. Angiotensin receptors, AT1 and AT2 homologues, have been identified… CONTINUE READING