Renin-angiotensin system blockade improves endothelial dysfunction in hypertension.

  title={Renin-angiotensin system blockade improves endothelial dysfunction in hypertension.},
  author={Kanako Goto and Koji Fujii and Uran Onaka and Isao Abe and Masatoshi Fujishima},
  volume={36 4},
Angiotensin-converting enzyme (ACE) inhibitor improves the impaired hyperpolarization and relaxation to acetylcholine (ACh) via endothelium-derived hyperpolarizing factor (EDHF) in arteries of spontaneously hypertensive rats (SHR). We tested whether the angiotensin type 1 (AT(1)) receptor antagonist also improves EDHF-mediated responses and whether the combined AT(1) receptor blockade and ACE inhibition exert any additional effects. SHR were treated with either AT(1) receptor antagonist TCV-116… CONTINUE READING


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