Renin-angiotensin-aldosterone system in brain infarction and vascular death.

  title={Renin-angiotensin-aldosterone system in brain infarction and vascular death.},
  author={David Brenner and J Labreuche and Odette Poirier and François Cambien and Pierre Amarenco},
  journal={Annals of neurology},
  volume={58 1},
The renin-angiotensin-aldosterone system has functions that may contribute to brain infarction (BI). In 459 matched pairs of white patients and control subjects, we measured plasma angiotensin-converting enzyme (ACE) levels, seven polymorphisms (angiotensinogen T174M and M235T, ACE I/D and 4656 2/3CT repeat [rpt], angiotensin II type 1 receptor A1166C and A153G, and aldosterone synthase CYP11B2), and evaluated 5-year poststroke mortality. Mean plasma ACE levels (+/-standard error) were… CONTINUE READING