Renin-activation by kallikrein: evidence for alkaline-activation of plasma renin.

Abstract

Porcine pancreatic kallikrein leads to a significant activation of human plasma renin when incubated at pH 8.2. 'Endogenous' activation of plasma renin can be seen by incubation of plasmas at the same pH. Both 'endogenous' alkaline- and kallikrein-activation of plasma renin can be inhibited by aprotinin. Both, kallikrein- and 'endogenous' alkaline activation of plasma renin are significantly correlated to cryo- and acid-activation. We suggest that kallikrein-and 'endogenous' alkaline-activiation come close to the in vivo activation process.

Cite this paper

@article{Hummerich1979ReninactivationBK, title={Renin-activation by kallikrein: evidence for alkaline-activation of plasma renin.}, author={W. Hummerich and H. Feltkamp and A. Konrads and P Ahlmann and H Bornhofen}, journal={European journal of clinical investigation}, year={1979}, volume={9 6}, pages={447-9} }