Renin-Angiotensin System Blockers Protect Pancreatic Islets against Diet-Induced Obesity and Insulin Resistance in Mice

@inproceedings{Frantz2013ReninAngiotensinSB,
  title={Renin-Angiotensin System Blockers Protect Pancreatic Islets against Diet-Induced Obesity and Insulin Resistance in Mice},
  author={Eliete Dalla Corte Frantz and Camila Crespo-Mascarenhas and Andr{\'e} Rodrigues da Cunha Barreto-Vianna and M{\'a}rcia Barbosa {\'A}guila and Carlos Alberto Mandarim-de-Lacerda},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND The associations between obesity, hypertension and diabetes are well established, and the renin-angiotensin system (RAS) may provide a link among them. The effect of RAS inhibition on type 2 diabetes is still unclear; however, RAS seems to play an important role in the regulation of the pancreas and glucose intolerance of mice fed high-fat (HF) diet. METHODS C57BL/6 mice fed a HF diet (8 weeks) were treated with aliskiren (50 mg/kg/day), enalapril (30 mg/kg/day) or losartan (10 mg… CONTINUE READING

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