Renin–angiotensin system in ureteric bud branching morphogenesis: implications for kidney disease

@article{Yosypiv2013ReninangiotensinSI,
  title={Renin–angiotensin system in ureteric bud branching morphogenesis: implications for kidney disease},
  author={Ihor V. Yosypiv},
  journal={Pediatric Nephrology},
  year={2013},
  volume={29},
  pages={609-620}
}
Failure of normal branching morphogenesis of the ureteric bud (UB), a key ontogenic process that controls organogenesis of the metanephric kidney, leads to congenital anomalies of the kidney and urinary tract (CAKUT), the leading cause of end-stage kidney disease in children. Recent studies have revealed a central role of the renin–angiotensin system (RAS), the cardinal regulator of blood pressure and fluid/electrolyte homeostasis, in the control of normal kidney development. Mice or humans… CONTINUE READING

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