Renegade nuclear enzymes disrupt axonal integrity

  title={Renegade nuclear enzymes disrupt axonal integrity},
  author={Robert H. Miller},
  journal={Nature Neuroscience},
The author is in the Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA. e-mail: HDAC1 was localized to the cytoplasm in tissue samples from multiple sclerosis patients only in regions of demyelination. To interrogate an experimental model, the authors utilized the mouse model of cuprizone-induced demyelination. This model consists of feeding animals a diet containing the copper chelator cuprizone, which results in localized… CONTINUE READING