Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons.

@article{Cowan2000RenalXF,
  title={Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons.},
  author={Peter J Cowan and Atefeh Aminian and Hilda Barlow and Amalia A Brown and Caleb Gon-Shen Chen and Nella Fisicaro and David Michael Francis and David J Goodman and Wenruo Han and Michał Kurek and Mark B. Nottle and Martin John Pearse and Evelyn J Salvaris and Trixie A Shinkel and G V Stainsby and Anne B Stewart and Anthony J. F. d'Apice},
  journal={Transplantation},
  year={2000},
  volume={69 12},
  pages={2504-15}
}
BACKGROUND The genetic modification of pigs is a powerful strategy that may ultimately enable successful xenotransplantation of porcine organs into humans. METHODS Transgenic pigs were produced by microinjection of gene constructs for human complement regulatory proteins CD55 and CD59 and the enzyme alpha1,2-fucosyltransferase (H-transferase, HT), which reduces expression of the major xenoepitope galactose-alpha1,3-galactose (alphaGal). Kidneys from CD55/HT and CD55/CD59/HT transgenic pigs… CONTINUE READING

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