Renal vasodilation induced by hypernatraemia: role of alpha-adrenoceptors in the median preoptic nucleus.

@article{Pedrino2009RenalVI,
  title={Renal vasodilation induced by hypernatraemia: role of alpha-adrenoceptors in the median preoptic nucleus.},
  author={Gustavo Rodrigues Pedrino and Luciana R Monaco and Sergio Luiz Domingues Cravo},
  journal={Clinical and experimental pharmacology & physiology},
  year={2009},
  volume={36 12},
  pages={e83-9}
}
1. The renal vasodilation induced by infusion of hypertonic saline (HS) in anaesthetized rats has been shown to depend on the integrity of the median preoptic nucleus (MnPO), as well as noradrenergic afferents to this nucleus. In the present study, we sought to determine the role of alpha(1) and alpha(2)-adrenoceptors in the MnPO in cardiovascular responses induced by intravenous HS infusion (3 mol/L NaCl; 1.8 mL/kg, i.v., over 1 min). 2. Male Wistar rats (320-360 g) were anaesthetized with… CONTINUE READING
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