Renal tubular impairment in children with idiopathic hypercalciuria.

  title={Renal tubular impairment in children with idiopathic hypercalciuria.},
  author={Sylvia Skalova and Stěp{\'a}n Kut{\'i}lek},
  journal={Acta medica},
  volume={49 2},
Idiopathic hypercalciuria (IH) is defined as hypercalciuria that persists after correction of dietary inbalances and has no detectable cause. The excretion of urinary N-acetyl-beta-D-glucosaminidase (U-NAG), a marker of proximal tubular damage, has been previously reported as either increased or normal in children with IH. We evaluated U-NAG in 20 children (13 boys and 7 girls, mean age 10.3 years +/- 5.7 SD) with IH (urinary calcium excretion above 0.1 mmol/kg/24 hours, with no detectable… CONTINUE READING