Corpus ID: 37826649

Renal tubular function in beta-thalassemia.

  title={Renal tubular function in beta-thalassemia.},
  author={A. Sumboonnanonda and P. Malasit and V. Tanphaichitr and S. Ong-ajyooth and S. Sunthornchart and S. Pattanakitsakul and S. Petrarat and A. Assateerawatt and A. Vongjirad},
  journal={Pediatric nephrology},
  volume={12 4},
Studies of the renal involvement in thalassemic syndromes have been varied and few. This study was designed to define the renal abnormalities associated with beta-thalassemia and to correlate the renal findings with clinical parameters. One hundred and four beta-thalassemic children with various disease severity were studied. The patients were divided into three groups: 48 with severe anemia [hematocrit (Hct) < 25%], 31 on a hypertransfusion program and desferrioxamine treatment, and 25 with… Expand
Renal function in children with β-thalassemia major and thalassemia intermedia
It is found that renal tubular function is impaired in children with β- thalassemia major and intermedia and whether these functional abnormalities would have any long-term effects on the patients is not known. Expand
Renal Tubular Dysfunction in -Thalassemia Minor
Proximal renal tubular dysfunction is not rare in patients with -thalassemia minor, and anemic patients had increased urinary zinc excretion and fractional excretion of sodium and uric acid compared with both controls and patients without anemia. Expand
Early markers of renal dysfunction in patients with beta-thalassemia major
It is concluded that renal disorders are not rare in patients with beta-thalassemia major and that they may increase in terms of frequency with age, increased duration of transfusion and deferoxamine usage and high levels of blood sugar. Expand
Hematuria in patients with Beta-thalassemia major.
It is found that in patients with beta-thalassemia major, the risk of hematuria rises with age, and proteinuria seems to be more common in those with hematurio, while Sterile pyuria was detected in 4% andproteinuria in 16% of the patients with Hematuria, while these figures in patients without hematurIA were 2.1% and 1.4% respectively. Expand
Glomerular Hyperfiltration and Proteinuria in Transfusion-Independent Patients with β-Thalassemia Intermedia
A considerable proportion of TI patients show evidence of abnormally elevated eGFR, with a declining trend towards advancing age, and the occurrence of proteinuria is associated with anemia, hemolysis and iron toxicity. Expand
Subclinical renal abnormalities in young thalassemia major and intermedia patients and its relation to chelation therapy
Poor chelation is associated with early signs of renal affection in children and adolescents with b-thalassemia major and intermedia and can start earlier in TM patients compared to TI, according to this study. Expand
Renal functions in pediatric patients with beta-thalassemia major: relation to chelation therapy: original prospective study
High frequency of glomerular and tubular dysfunctions in TD-βTM pediatric patients which could be attributed to oxidative stress and DFO therapy is confirmed. Expand
Kidney function tests in children with beta-thalassemia minor in Zahedan, southeast of Iran.
The findings support the existence of renal tubular dysfunction in beta-thalassemia minor and further studies in large series are needed to shed light on the possible relation of these two distinct diseases. Expand
A Prospective Study of Tubular Dysfunction in Pediatric Patients with Beta Thalassemia Major Receiving Deferasirox
The findings highlighted tubular nephropathy induced by Deferasirox in patients with beta thalassemia, and confirmed the necessity for diligent monitoring of renal function in thalassesmia patients receiving Defer asirox. Expand
Renal tubular function in patients with beta-thalassaemia major in Zahedan, southeast Iran.
The determination of biochemical indices of renal function might help prevention of serious kidney damage before any clinical symptom is observed and suggest the appropriate chelation therapy and regular monitoring of the status of iron overload. Expand