Renal tubular Notch signaling triggers a prosenescent state after acute kidney injury.

  title={Renal tubular Notch signaling triggers a prosenescent state after acute kidney injury.},
  author={Inga S{\"o}rensen-Zender and Song Rong and Nathan Susnik and Steffen Zender and Petra Pennekamp and Anette Melk and Hermann Haller and Roland Schmitt},
  journal={American journal of physiology. Renal physiology},
  volume={306 8},
The aging kidney has a diminished regenerative potential and an increased tendency to develop tubular atrophy and fibrosis after acute injury. In this study, we found that activation of tubular epithelial Notch1 signaling was prolonged in the aging kidney after ischemia/reperfusion (IR) damage. To analyze the consequences of sustained Notch activation, we generated mice with conditional inducible expression of Notch1 intracellular domain (NICD) in proximal tubules. NICD kidneys were analyzed 1… 

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