Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

@article{Mii2011RenalTM,
  title={Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.},
  author={Akiko Mii and Akira Shimizu and Tomohiro Kaneko and Emiko Fujita and Megumi Fukui and Teppei Fujino and Kouichi Utsumi and Hiroki Yamaguchi and Kenji Tajika and Shinichi Tsuchiya and Yasuhiko Iino and Yasuo Katayama and Yuh Fukuda},
  journal={Pathology international},
  year={2011},
  volume={61 9},
  pages={518-27}
}
Thrombotic microangiopathy (TMA) is a major complication after hematopoietic stem cell transplantation (HSCT). In this study, we examined the clinical and pathologic features of 2 patients and 5 autopsy cases with HSCT-associated renal TMA to clarify the association between graft-versus-host disease (GVHD) and renal TMA. The median interval between HSCT and renal biopsy or autopsy was 7 months (range 3-42 months). Clinically, acute and chronic GVHD occurred in 7 and 4 patients, respectively… CONTINUE READING
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