Renal targeting of arginine-vasopressin by modification with carbohydrates at the tyrosine side chain.

Abstract

To extend the utility of a renal targeting system using carbohydrate derivatives, we investigated the in vivo tissue distribution in rats of arginine-vasopressin (AVP) derivatives modified at the phenolic hydroxy group of tyrosine by linking it to some sugars, namely D-glucose, D-galactose, D-mannose and L-fucose, via an octamethylene group. The glycosyl… (More)

Topics

Cite this paper

@article{Susaki1999RenalTO, title={Renal targeting of arginine-vasopressin by modification with carbohydrates at the tyrosine side chain.}, author={Hitoshi Susaki and K. Suzuki and H. Yamada and Shiro Okuno and Hisako Watanabe}, journal={Biological & pharmaceutical bulletin}, year={1999}, volume={22 10}, pages={1094-8} }