Renal sympathetic nerve activity after dexmedetomidine in nerve-intact and baroreceptor-denervated rabbits.

@article{Oku1996RenalSN,
  title={Renal sympathetic nerve activity after dexmedetomidine in nerve-intact and baroreceptor-denervated rabbits.},
  author={Shouzou Oku and Kirk T Benson and M. Hirakawa and Hiroshi Goto},
  journal={Anesthesia and analgesia},
  year={1996},
  volume={83 3},
  pages={477-81}
}
To determine the effects of intravenous dexmedetomidine (DMED) on the sympathetic nervous system and to elucidate the mechanism of hypotension, we administered 3 micrograms/kg of DMED to nerve-intact and baroreceptor-denervated rabbits and compared the changes in renal sympathetic nerve activity (RSNA) and hemodynamic variables. In nerve-intact animals, mean arterial pressure (MAP) was increased briefly and then decreased significantly. Changes in RSNA were reciprocal to those of MAP. Heart… CONTINUE READING

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