Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation.

@article{Rafiq2012RenalSD,
  title={Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation.},
  author={Kazi Rafiq and Takahisa Noma and Yoshihide Fujisawa and Yasuhiro Ishihara and Yoshie Arai and Ahm H. M. Nurun Nabi and Fumiaki Suzuki and Yukiko Nagai and Daisuke Nakano and Hirofumi Hitomi and Kento Kitada and Maki Urushihara and Hiroyuki Kobori and Masakazu Kohno and Akira Nishiyama},
  journal={Circulation},
  year={2012},
  volume={125 11},
  pages={1402-13}
}
BACKGROUND The presence of chronic kidney disease is a significant independent risk factor for poor prognosis in patients with chronic heart failure. However, the mechanisms and mediators underlying this interaction are poorly understood. In this study, we tested our hypothesis that chronic cardiac volume overload leads to de novo renal dysfunction by coactivating the sympathetic nervous system and renin-angiotensin system in the kidney. We also examined the therapeutic potential of renal… CONTINUE READING
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