Renal sodium handling in acute and chronic salt loading/depletion protocols: the confounding influence of acute water loading.

@article{Burnier2000RenalSH,
  title={Renal sodium handling in acute and chronic salt loading/depletion protocols: the confounding influence of acute water loading.},
  author={Michel Burnier and Maxime Monod and Arnaud Chiolero and Marc Maillard and Juerg Nussberger and Hans Rudolf Brunner},
  journal={Journal of hypertension},
  year={2000},
  volume={18 11},
  pages={1657-64}
}
OBJECTIVES Renal tubular sodium handling was measured in healthy subjects submitted to acute and chronic salt-repletion/salt-depletion protocols. The goal was to compare the changes in proximal and distal sodium handling induced by the two procedures using the lithium clearance technique. METHODS In nine subjects, acute salt loading was obtained with a 2 h infusion of isotonic saline, and salt depletion was induced with a low-salt diet and furosemide. In the chronic protocol, 15 subjects… CONTINUE READING

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