Renal scarring by mannose-sensitive adhesin of Escherichia coli type 1 pili.

@article{Mizunoe1997RenalSB,
  title={Renal scarring by mannose-sensitive adhesin of Escherichia coli type 1 pili.},
  author={Yoshimitsu Mizunoe and Tetsuro Matsumoto and M. Sakumoto and Shinji Kubo and O. Mochida and Yukihiro Sakamoto and Joichi Kumazawa},
  journal={Nephron},
  year={1997},
  volume={77 4},
  pages={412-6}
}
Most Escherichia coli isolates from patients with pyelonephritis possess both pap (mannose-resistant) pili and type 1 (mannose-sensitive) pili. In the experimental pyelonephritis model of rats, the mannose-sensitive-piliated strain caused severe renal scarring, whereas the mannose-resistant or nonpiliated strain did not. Type 1 pili consist of several subunits; one major subunit and other minor subunits. One of the minor subunits, adhesin, is responsible for mannose-sensitive adhesion to… CONTINUE READING

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