Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis

  title={Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis},
  author={Patrick D. Olson and Lisa K McLellan and Alice Liu and Kelleigh E Briden and Kristin M Tiemann and Allyssa L Daugherty and Keith A. Hruska and David A Hunstad},
  booktitle={Disease models & mechanisms},
We present a new preclinical model to study treatment, resolution and sequelae of severe ascending pyelonephritis. Urinary tract infection (UTI), primarily caused by uropathogenic Escherichia coli (UPEC), is a common disease in children. Severe pyelonephritis is the primary cause of acquired renal scarring in childhood, which may eventually lead to hypertension and chronic kidney disease in a small but important fraction of patients. Preclinical modeling of UTI utilizes almost exclusively… CONTINUE READING

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