Renal responses to intra-arterial administration of adrenomedullin in dogs.

  title={Renal responses to intra-arterial administration of adrenomedullin in dogs.},
  author={Dewan S.A. Majid and Philip J. Kadowitz and D. H. Coy. E. J. Coy and Luis Gabriel Navar},
  journal={The American journal of physiology},
  volume={270 1 Pt 2},
The present study was undertaken to evaluate the renal responses to intra-arterial infusion (12.5 for 30 min of adrenomedullin (ADM) in denervated kidneys of anesthetized dogs (n = 8). Total renal blood flow (RBF) was measured with an electromagnetic flow probe, and two single-fiber laser-Doppler needle flow probes were used to measure relative changes in cortical (CBF) and medullary blood flow (MBF). ADM administration resulted in decreases in renal vascular resistance (32.3… CONTINUE READING


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