Renal responses of the fetal lamb to fetal or maternal volume expansion.

@article{Hurley1977RenalRO,
  title={Renal responses of the fetal lamb to fetal or maternal volume expansion.},
  author={John K Hurley and Stanley E. Kirkpatrick and Paul T Pitlick and William F. Friedman and Stanley A. Mendoza},
  journal={Circulation research},
  year={1977},
  volume={40 6},
  pages={557-60}
}
Fetal and maternal glomerular filtration rate (GFR), renal plasma flow (RPF), urine volume, sodium excretion, and fractional sodium reabsorption were measured in a chronically instrumented sheep preparation. Fetal GFR was essentially stable between 110 and 135 days of gestation (term = 147 days). There was a significant increase in GFR after 135 days. After the infusion of 50 ml of normal saline over a 30-minute period, fetal GFR and sodium excretion increased significantly. Fractional sodium… CONTINUE READING

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