Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression.

@article{Agarwal2000RenalRT,
  title={Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression.},
  author={Anupam Agarwal and Harry S. Nick},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2000},
  volume={11 5},
  pages={965-73}
}
Heme oxygenase-1 (HO-1) is a microsomal enzyme involved in the degradation of heme, resulting in the generation of biliverdin, iron, and carbon monoxide. Recent attention has focused on the biologic effects of product(s) of this enzymatic reaction that have important antioxidant, anti-inflammatory, and cytoprotective functions. Induction of HO-1 occurs as an adaptive and beneficial response to a wide variety of oxidant stimuli, including heme, hydrogen peroxide, cytokines, growth factors, heavy… CONTINUE READING
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