Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent.

Abstract

BACKGROUND Thickening and reduplication of the tubular basement membrane have been reported as early events in diabetic nephropathy. In this study, we have examined the polar requirements of proximal tubular cells for the d-glucose-stimulated accumulation of fibronectin and the mechanism by which this occurred, with particular emphasis on the polyol pathway… (More)

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