Renal proximal and distal tubular function is attenuated in diabetes mellitus type 1 as determined by the renal excretion of α1-microglobulin and Tamm-Horsfall protein

@article{Pfleiderer1993RenalPA,
  title={Renal proximal and distal tubular function is attenuated in diabetes mellitus type 1 as determined by the renal excretion of α1-microglobulin and Tamm-Horsfall protein},
  author={S Johannes Pfleiderer and Lothar- Bernd Zimmerhackl and R. K. -H. Kinne and Friedrich Manz and Gregg H Schuler and Matthias Brandis},
  journal={The clinical investigator},
  year={1993},
  volume={71},
  pages={972-977}
}
Diabetic nephropathy is usually characterized by glomerular dysfunction; the view that tubular damage occurs as a consequence, however, has been disputed. To verify this hypothesis we compared glomerular with proximal and distal tubular parameters in 62 patients with diabetes mellitus type I. The duration of disease ranged between 0 and 39 years and the glomerular, proximal tubular, and distal tubular parameters were investigated in 24-h urine samples. Excretion of albumin as a marker of the… CONTINUE READING