Renal protective effect of chronic inhibition of COX-2 with SC-58236 in streptozotocin-diabetic rats.

Abstract

The induction of renal cyclooxygenase-2 (COX-2) in diabetes has been implicated in the renal functional and structural changes in models where hypertension or uninephrectomy was superimposed. We examined the protective effects of 3 mo treatment of streptozotocin-diabetic rats with a highly selective COX-2 inhibitor (SC-58236) in terms of albuminuria, renal… (More)
DOI: 10.1152/ajpheart.01259.2010

Topics

6 Figures and Tables

Cite this paper

@article{Quilley2011RenalPE, title={Renal protective effect of chronic inhibition of COX-2 with SC-58236 in streptozotocin-diabetic rats.}, author={John Quilley and Marisa Santos and Pablo Enrique Pedraza}, journal={American journal of physiology. Heart and circulatory physiology}, year={2011}, volume={300 6}, pages={H2316-22} }