Renal protection by a soy diet in obese Zucker rats is associated with restoration of nitric oxide generation.

@article{Trujillo2005RenalPB,
  title={Renal protection by a soy diet in obese Zucker rats is associated with restoration of nitric oxide generation.},
  author={Joyce Trujillo and V. Arag{\'o}n Ram{\'i}rez and Jazm{\'i}n P{\'e}rez and Iv{\'a}n Torre-Villalvazo and Nimbe Torres and Armando R. Tovar and Rosa Mar{\'i}a Mu{\~n}oz and Norma Uribe and Gerardo Gamba and Norma A Bobadilla},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={288 1},
  pages={F108-16}
}
The obese Zucker rat is a valuable model for studying kidney disease associated with obesity and diabetes. Previous studies have shown that substitution of animal protein with soy ameliorates the progression of renal disease. To explore the participation of nitric oxide (NO) and caveolin-1 in this protective effect, we evaluated proteinuria, creatinine clearance, renal structural lesions, nitrites and nitrates urinary excretion (UNO(2)(-)/NO(3)V), and mRNA and protein levels of neuronal NO… CONTINUE READING

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