Renal prostaglandins, kidney function and essential hypertension.

  title={Renal prostaglandins, kidney function and essential hypertension.},
  author={Peter C. Weber},
  journal={Contributions to nephrology},
In vivo and in vitro studies have shown that renal formation of prostaglandins (PG), most probably at the juxtaglomerular complex represents an essential step for the mechanisms regulating the secretion of renin. PGs formed in the cortex seem to participate also in the control of renal vascular resistance and glomerular filtration rate. Renal PG formation, especially that of PGE2, is reduced by high NaCl intake leading to a relative preponderance of PGF2 alpha at a reduced level of PG formation… CONTINUE READING