Renal parenchymal oxygenation and hypoxia adaptation in acute kidney injury.

@article{Rosenberger2006RenalPO,
  title={Renal parenchymal oxygenation and hypoxia adaptation in acute kidney injury.},
  author={C Rosenberger and Seymour Rosen and Samuel N Heyman},
  journal={Clinical and experimental pharmacology & physiology},
  year={2006},
  volume={33 10},
  pages={980-8}
}
The pathogenesis of acute kidney injury (AKI), formally termed acute tubular necrosis, is complex and, phenotypically, may range from functional dysregulation without overt morphological features to literal tubular destruction. Hypoxia results from imbalanced oxygen supply and consumption. Increasing evidence supports the view that regional renal hypoxia occurs in AKI irrespective of the underlying condition, even under circumstances basically believed to reflect 'direct' tubulotoxicity… CONTINUE READING