Renal papillary necrosis following phenacetin excess.

@article{Cochran1967RenalPN,
  title={Renal papillary necrosis following phenacetin excess.},
  author={Alistair J. Cochran and David H. Lawson and Adam L. Linton},
  journal={Scottish medical journal},
  year={1967},
  volume={12 7},
  pages={
          246-50
        }
}
REN A L papillary necrosis has been recognised as a pathological entity for many years. Early clinical reports suggested that while renal infection might be the direct cause of the condition, there was almost always an additional factor present, either diabetes mellitus or urinary tract obstruction. For example, Mandel in 1952 reviewed 160 cases of renal papillary necrosis reported in the literature, and found that diabetes or obstruction had been present in 144 of them. Over the past few years… 

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TLDR
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Patients are described who have both peptic ulcers and chronic renal disease together with a history of prolonged analgesic abuse. Psychological instability may predispose to the high analgesic

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TLDR
A comparison of the quantity of phenacetin ingested in this country with amounts consumed elsewhere would be of interest, and a survey on these lines has been attempted.

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TLDR
Now that the authors use endocardial jugular systems for long-term pacing, thereby avoiding a thoracotomy, the risk of ventricular fibrillation must be greatly reduced, and the risk was probably the unnecessarily high power of the earlier units.

NEPHROPATHY ASSOCIATED WITH THE USE OF ANALGESIC MEDICATIONS.

TLDR
The nephropathy associated with the use of analgesic medication has received wide notice recently, and detailed study and long-term follow-up study of patients reputed to have this problem are being conducted.

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