Renal microvascular injury in diabetes: RAGE and redox signaling.

  title={Renal microvascular injury in diabetes: RAGE and redox signaling.},
  author={Melinda T. Coughlan and Mark Emmanuel Cooper and Josephine M Forbes},
  journal={Antioxidants & redox signaling},
  volume={9 3},
Diabetic nephropathy remains a major cause of morbidity and mortality in the diabetic population and is the leading cause of end-stage renal failure in the Western World. Despite current therapeutics including intensified glycemic control and blood pressure lowering agents, renal disease continues to progress relentlessly in diabetic patients, albeit at a lower rate. It is well recognized that metabolic and hemodynamic factors play a central role in accelerating renal disease in diabetes… CONTINUE READING


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