Renal metabolism and urinary excretion of platelet-activating factor in the rat.

@article{Noris1990RenalMA,
  title={Renal metabolism and urinary excretion of platelet-activating factor in the rat.},
  author={Marina Noris and Norberto Perico and Daniela Macconi and V. Nanni and Jacek Dadan and F Peterlongo and Giuseppe Remuzzi},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 32},
  pages={19414-9}
}
The origin of platelet-activating factor (PAF) in the urine remains ill defined. The present study documents that [3H]PAF (3.5 mu Ci) injected into the renal artery of isolated control rat kidney preparations perfused at constant pressure with a cell-free medium containing 1% bovine serum albumin (BSA) was excreted in negligible amounts (0.034%) in the urine, whereas 6% was retained by the kidney. When kidneys were perfused with a BSA-free medium, 0.029 and 71% of the total radioactivity added… CONTINUE READING
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