Renal medullary oxidative stress, pressure-natriuresis, and hypertension.

  title={Renal medullary oxidative stress, pressure-natriuresis, and hypertension.},
  author={Allen W. Cowley},
  volume={52 5},
Renal dysfunction has long been a recognized feature of essential hypertension as first suggested by Dr Richard Bright’s mid-19th century observations of small, shrunken, scarred kidneys associated with cardiac hypertrophy and the seminal studies in the 1930s by Dr Harry Goldblatt directly linking the kidney to chronic hypertension. Attention was originally and appropriately focused on the renal cortex, which represents more than 90% of the renal mass, is the site of glomerular filtration, and… CONTINUE READING