Renal medullary effects of transient prehypertensive treatment in young spontaneously hypertensive rats.

@article{Baumann2009RenalME,
  title={Renal medullary effects of transient prehypertensive treatment in young spontaneously hypertensive rats.},
  author={Marcus Baumann and Ben J. A. Janssen and J. J. Rob Hermans and Roger Bartholom{\'e} and Jos F. M. Smits and Harry A J Struijker Boudier},
  journal={Acta physiologica},
  year={2009},
  volume={196 2},
  pages={231-7}
}
AIM Transient angiotensin II receptor blockade (ARB) leads to prolonged blood pressure (BP) lowering, but the underlying mechanism remains uncertain. Long-term BP control is regulated by the medullary microcirculation with the pericyte as contractile cell. We hypothesize that the prolonged BP effect is caused by increased medullary blood flow (MBF) associated with structural alterations based on reduced medullary pericyte number. METHODS Four-week-old spontaneously hypertensive rats (SHR… CONTINUE READING