Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice: Detection by association analysis of stone-related gene expression and microstructural observation.

@article{Okada2010RenalMM,
  title={Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice: Detection by association analysis of stone-related gene expression and microstructural observation.},
  author={Atsushi Okada and Takahiro Yasui and Yasuhiro Shimadzu Corpor Fujii and Kazuhiro Niimi and Yasuhiro Fujii and Masahito Hirose and Yoshiyuki Kojima and Keiichi Tozawa and Yutaro Hayashi and Masayuki Usami},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2010},
  volume={25 12},
  pages={
          2701-11
        }
}
Mice have a strong ability to eliminate renal calcium oxalate crystals, and our previous examination indicated a susceptibility in which monocyte-macrophage interaction could participate in the phenomenon. To clarify the macrophage-related factors playing roles in the prevention of crystal formation in mouse kidneys, morphologic and expression studies based on microarray pathway analysis were performed. Eight-week-old male C57BL/6N mice were administered 80 mg/kg of glyoxylate by daily… CONTINUE READING
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