Renal localization of the membrane attack complex in systemic lupus erythematosus nephritis

@article{Biesecker1981RenalLO,
  title={Renal localization of the membrane attack complex in systemic lupus erythematosus nephritis},
  author={G E Biesecker and Stephen M. Katz and David Koffler},
  journal={The Journal of Experimental Medicine},
  year={1981},
  volume={154},
  pages={1779 - 1794}
}
The membrane attack complex (MAC) of the complement system was localized in both glomeruli and peritubular regions of 22 kidneys manifesting systemic lupus erythematosus (SLE) nephritis. A similar distribution was observed for immune complex markers (IgG, Clq, and C3) and MAC in glomeruli, although the deposits of MAC were more discrete and showed lesser immunofluorescence staining intensity compared with immunoglobulins and complement components. In contrast, peritubular immune complexes were… CONTINUE READING
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The Immunopathology of the Kidney

  • B. Albini, J. R. Brentjens, G. A. Andres
  • Edward Arnold (Publishers) Ltd.,
  • 1979
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