Renal localization and function of the tight junction protein, claudin-19.

@article{Angelow2007RenalLA,
  title={Renal localization and function of the tight junction protein, claudin-19.},
  author={Susanne Angelow and Randa El-Husseini and Sanae A. Kanzawa and Alan S L Yu},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 1},
  pages={F166-77}
}
Claudins form a family of transmembrane tight junction proteins that play a key role in control and selectivity of paracellular transport. Mutations in claudin-19, which is expressed in kidney, retina, and myelinated peripheral neurons, were identified in familial hypomagnesemia with hypercalciuria and nephrocalcinosis, a hereditary disease causing renal Mg(2+) and Ca(2+) wasting. Here, we studied the distribution and possible functional role of claudin-19 in the renal tubule. By… CONTINUE READING
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