Renal lesions in spontaneous insulin-dependent diabetes mellitus in the nonobese diabetic mouse: acute phase of diabetes.

@article{Maeda2003RenalLI,
  title={Renal lesions in spontaneous insulin-dependent diabetes mellitus in the nonobese diabetic mouse: acute phase of diabetes.},
  author={Michie Maeda and Akira Yabuki and Syusaku Suzuki and Mitsuharu Matsumoto and Kazuyuki Taniguchi and Hayao Nishinakagawa},
  journal={Veterinary pathology},
  year={2003},
  volume={40 2},
  pages={187-95}
}
The nonobese diabetic mouse is a model of spontaneous insulin-dependent diabetes mellitus. The present study made longitudinal observations of renal lesions in the acute-progressive phase of diabetic mice 0, 10, 20, 30, and 40 days after onset of diabetes without insulin therapy. Plasma creatinine and blood urea nitrogen concentrations gradually increased after onset of diabetes. Kidney weight increased and plateaued at day 20. Under electron microscopy the glomeruli demonstrated only mild… CONTINUE READING

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