Renal kallikrein excretion and epigenetics in human acute kidney injury: Expression, mechanisms and consequences

@inproceedings{Kang2011RenalKE,
  title={Renal kallikrein excretion and epigenetics in human acute kidney injury: Expression, mechanisms and consequences},
  author={Sun Woo Sophie Kang and Pei-an Betty Shih and Roy O. Mathew and Manjula Mahata and N. B. Ghosh Biswas and Fangwen Rao and Liying Yan and Jos{\'e}e Bouchard and Rakesh Malhotra and Ashita J Tolwani and Srikrishna Khandrika and Ravindra L Mehta and Daniel T. O'Connor},
  booktitle={BMC nephrology},
  year={2011}
}
BACKGROUND Renal kallikrein (KLK1) synthesis and urinary excretion are reportedly diminished during AKI (acute kidney injury) in animal models, and provision of kallikrein abrogates renal injury in this setting, but data in human AKI is limited. Therefore we first examined KLK1 renal excretion in human AKI, and then probed potential endocrine and epigenetic mechanisms for its alterations. METHODS KLK1 enzymatic activity excretion was evaluated in urine from patients with established or… CONTINUE READING
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