Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone.

@article{MejaVilet2007RenalII,
  title={Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone.},
  author={Juan Manuel Mej{\'i}a-Vilet and V. Arag{\'o}n Ram{\'i}rez and Cristino Cruz and Norma Uribe and Gerardo Gamba and Norma A Bobadilla},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 1},
  pages={F78-86}
}
Renal ischemia and reperfusion (I/R) injury is the major cause of acute renal failure and may also be involved in the development and progression of some forms of chronic kidney disease. We previously showed that a mineralocorticoid receptor (MR) blockade prevents renal vasoconstriction induced by cyclosporine that leads to acute and chronic renal failure (Feria I, Pichardo I, Juarez P, Ramirez V, Gonzalez MA, Uribe N, Garcia-Torres R, Lopez-Casillas F, Gamba G, Bobadilla NA. Kidney Int 63: 43… CONTINUE READING