Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone.

Abstract

Renal ischemia and reperfusion (I/R) injury is the major cause of acute renal failure and may also be involved in the development and progression of some forms of chronic kidney disease. We previously showed that a mineralocorticoid receptor (MR) blockade prevents renal vasoconstriction induced by cyclosporine that leads to acute and chronic renal failure… (More)

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@article{MejaVilet2007RenalII, title={Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone.}, author={Juan Manuel Mej{\'i}a-Vilet and V. Ram{\'i}rez and C H Brito Cruz and Norma Uribe and Gerardo Gamba and Norma A Bobadilla}, journal={American journal of physiology. Renal physiology}, year={2007}, volume={293 1}, pages={F78-86} }