Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor.

@article{Basile2008RenalIR,
  title={Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor.},
  author={D P Basile and Katherine M. Fredrich and Bhadrani Chelladurai and Ellen C Leonard and Alan R. Parrish},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={294 4},
  pages={F928-36}
}
Reductions in vascular density occur following acute ischemia-reperfusion (I/R) injury that may predispose the development of chronic kidney disease. The mechanisms mediating vascular loss are not clear but may relate to the lack of effective vascular repair responses. To determine the regulation of the VEGF/VEGFR pathway following I/R injury, male Sprague-Dawley rats were subjected to bilateral renal ischemia (45 min) and allowed to recover for 1, 3, 7, and 35 days. VEGF mRNA expression was… CONTINUE READING
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Vascular endothelial cell growth factor and its receptors

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