Renal ischemia and reperfusion impair endothelium-dependent vascular relaxation.

@article{Lieberthal1989RenalIA,
  title={Renal ischemia and reperfusion impair endothelium-dependent vascular relaxation.},
  author={Wilfred Lieberthal and E F Wolf and Helmut G. Rennke and Cesare Robert Valeri and Norman G. Levinsky},
  journal={The American journal of physiology},
  year={1989},
  volume={256 5 Pt 2},
  pages={
          F894-900
        }
}
We studied the hemodynamic response of the isolated erythrocyte-perfused kidney to 25 min of ischemia and found that renal vascular resistance (RVR) was increased in the reflow period (16.7 +/- 1.4 mmHg.ml-1.min.g following ischemia vs. 10.2 +/- 0.8 mmHg.ml-1.min.g in control kidneys). Endothelial independent vasodilators [atrial natriuretic factor (ANF) and sodium nitroprusside] prevented the increase in RVR that occurred after ischemia. In contrast, acetylcholine and the calcium ionophore… CONTINUE READING
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