Renal histopathologic alterations in patients treated with cyclosporine for uveitis.

  title={Renal histopathologic alterations in patients treated with cyclosporine for uveitis.},
  author={Alan Gary Palestine and Howard Austin and James E. Balow and T T Antonovych and Sharda G Sabnis and Harry G. Preuss and Robert B. Nussenblatt},
  journal={The New England journal of medicine},
  volume={314 20},
To evaluate abnormalities of renal morphology associated with long-term cyclosporine therapy, we obtained percutaneous renal biopsy specimens from 17 patients who had been treated for autoimmune uveitis with cyclosporine for an average of two years. For comparison, we also analyzed renal biopsy specimens from patients with idiopathic hematuria who had not received cyclosporine. The atrophic and sclerosing glomerular and tubulointerstitial lesions in the specimens were assessed to derive a… CONTINUE READING


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