Renal hemodynamics and blood flow autoregulation during acute cyclooxygenase inhibition in male rats.

@article{Kramp1995RenalHA,
  title={Renal hemodynamics and blood flow autoregulation during acute cyclooxygenase inhibition in male rats.},
  author={Roger Kramp and J Genard and P Fourmanoir and Nathalie Caron and G. L. Laekeman and Arnold Herman},
  journal={The American journal of physiology},
  year={1995},
  volume={268 3 Pt 2},
  pages={F468-79}
}
After the acute inhibition of prostanoid synthesis, adjustments of renal hemodynamics may not be characterized immediately. Therefore, time-related effects of indomethacin on hemodynamics and renal blood flow (RBF) autoregulation were studied in anesthetized euvolemic male rats injected intravenously with vehicle, indomethacin (3, 4, or 5 mg/kg body wt), or meclofenamate (4 or 5 mg/kg body wt). Hemodynamics and RBF autoregulation were not influenced by vehicle injection, nor by time (n = 6). In… CONTINUE READING