Renal functional reserve in experimental chronic glomerulonephritis.

  title={Renal functional reserve in experimental chronic glomerulonephritis.},
  author={Luca De Nicola and Orjan W Peterson and Suzan Obagi and J. A. C. Kaiser and Curtis B. Wilson and Francis B Gabbai},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={9 10},
Loss of renal functional reserve, that is, absence of the glomerular vasodilatory response to amino-acid infusion, has been interpreted as equivalent to glomerular hyperperfusion/hypertension, and therefore proposed as a marker of high risk for progressive glomerular sclerosis. To substantiate the validity of this hypothesis we evaluated the renal response to glycine and the extent of glomerular damage 10-12 weeks after induction of anti-glomerular basement membrane glomerulonephritis with or… CONTINUE READING