Renal function and hyperfiltration capacity in lead smelter workers with high bone lead.

@article{Roels1994RenalFA,
  title={Renal function and hyperfiltration capacity in lead smelter workers with high bone lead.},
  author={Harry A. Roels and Robert R. Lauwerys and Joke Konings and J. P. Buchet and Alfred Bernard and Sandra Green and Deborah Bradley and Wayne Morgan and David R. Chettle},
  journal={Occupational and environmental medicine},
  year={1994},
  volume={51 8},
  pages={505-12}
}
OBJECTIVE The study was undertaken to assess whether the changes in urinary excretion of eicosanoids (a decrease of 6-keto-PGF1 alpha and PGF2 and an increase of thromboxane) previously found in lead (Pb) exposed workers may decrease the renal haemodynamic response to an acute oral protein load. METHODS The renal haemodynamic response was estimated by determining the capacity of the kidney to increase the glomerular filtration rate (in terms of creatinine clearance) after an acute consumption… CONTINUE READING