Renal function adaptation up to the fifth decade after treatment of children with unilateral renal tumor: A cross‐sectional and longitudinal study

@article{Cozzi2013RenalFA,
  title={Renal function adaptation up to the fifth decade after treatment of children with unilateral renal tumor: A cross‐sectional and longitudinal study},
  author={Denis A. Cozzi and Silvia Ceccanti and Simone Frediani and Ermelinda Mele and Francesco Cozzi},
  journal={Pediatric Blood \& Cancer},
  year={2013},
  volume={60}
}
Mild‐to‐moderate renal function loss may be an independent risk factor for cardiovascular disease and overall mortality. As in adults with renal carcinoma nephrectomy is associated with an high risk for moderate renal function loss, we aimed to assess the renal function adaptation over a long period of time in children with unilateral renal tumor (URT). 
View on Wiley
slaop.org
45 Citations
Highly Influential Citations
2
Background Citations
18
Methods Citations
1
Results Citations
1

45 Citations

Citation Type

Citation Type

Long‐term renal function in unilateral non‐syndromic renal tumor survivors treated according to International Society of Pediatric Oncology protocols
TLDR
The prevalence of and possible risk factors for renal impairment are evaluated by estimating Glomerular Filtration Rate categories and chronic kidney disease (CKD) according to Kidney Disease: Improving Global Outcomes guidelines.
Renal function up to the 5th decade of life after nephrectomy in childhood: A literature review
TLDR
Stratification of all survivors for age revealed the number of subjects with blood hypertension and/or renal dysfunction to be significantly higher in survivors ≥30 years old in comparison with younger patients.
Comment on: Long‐Term Renal Function in Unilateral Non‐Syndromic Renal Tumor Survivors Treated According to International Society of Pediatric Oncology Protocols
TLDR
A meta-analysis of studies on GFR estimated by MDRD or the Cockcroft-Gault equation has come to the conclusion that an eGFR <90ml/min/1.73m is associated with a 20–30% increase in risk of major vascular events and death from any cause at an age of 70 years.
Paediatrics: Long-term effects of Wilms tumour therapy on renal function
TLDR
The long-term effects of radical nephrectomy on renal function have not been well studied but new data have given some insight into the lasting outcomes of this surgery.
RE: Evaluation of renal function after successful treatment for unilateral non‐syndromic Wilms tumor
TLDR
The conclusion that renal dysfunction based on glomerular filtration rate measurements with various standard methods (GFR) may be due to abdominal irradiation is not supported by available data and it is suggested that not only congenital but also acquired single kidney requires a life-long renal function follow-up.
Prospective analysis of long-term renal function in survivors of childhood Wilms tumor
TLDR
Even though WT-S are believed to carry a low risk for end-stage renal disease, in this study, a remarkable number ofWT-S presented with previously unidentified subclinical signs of renal function impairment and secondary morbidity, Therefore, it is important to continue regular follow-up, especially after transition into adulthood.
Long‐term renal outcome in adolescent and young adult patients nephrectomized for unilateral Wilms tumor
TLDR
The experience of the long-term renal impact of unilateral total nephrectomy combined with chemotherapy for low-stage WT appears to confirm the safety of this therapeutic approach, although careful renal function and blood pressure monitoring is recommended at least every 5 years.
Comment on: Long‐term renal function after treatment for unilateral nonsyndromic Wilms’ tumor—A personal perspective
TLDR
Interestingly, the authors found that nephrectomy during childhood was associated with an increase in prevalence of hypertension that was not present many years before, suggesting a progressive deterioration.
Renal function in patients with Wilms tumor.
Renal Late Effects After the Treatment of Unilateral Nonsyndromic Wilms Tumor
TLDR
Late renal effects of the treatment on 50 survivors of nonsyndromic unilateral Wilms tumor investigated, finding no end-stage renal disease and a significant decreasing trend in the GFR with longer follow-up intervals.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Kidney function in adults born with unilateral renal agenesis or nephrectomized in childhood
TLDR
It is concluded that in patients with a single kidney since childhood the long-term prognosis is good, but the late decrease in GFR and increase in albumin excretion may indicate a moderate risk for premature renal damage.
Renal function up to 50 years after unilateral nephrectomy in childhood.
Chronic kidney disease in children with unilateral renal tumor.
LONG-TERM FOLLOW-UP OF PATIENTS WHO UNDERWENT UNILATERAL NEPHRECTOMY IN CHILDHOOD
Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study.
End Stage and Chronic Kidney Disease: Associations with Renal Cancer
TLDR
Despite emerging evidence that PN provides equivalent local tumor control to RN while at the same time preventing CKD, this operation remains under utilized in the United States and abroad.
Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction.
TLDR
Even mild renal disease, as assessed by the estimated GFR, should be considered a major risk factor for cardiovascular complications after a myocardial infarction.
Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States.
TLDR
This study indicates that, in a representative sample of the United States general population, renal insufficiency is independently associated with increased cardiovascular disease-related and all-cause mortality rates.
Long-term outcome of nephron sparing surgery and simple nephrectomy for unilateral localized Wilms tumor.
TLDR
The authors' results are similar to those achieved by radical nephrectomy in previous studies, and leaving Gerota's fascia in situ does not seem to confer a higher risk of local recurrence in patients with low stage nonanaplastic WT.
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.
...
1
2
...