Renal fibrosis: an update.

@article{Zeisberg2001RenalFA,
  title={Renal fibrosis: an update.},
  author={Michael Zeisberg and Frank M Strutz and Gerhard A. M{\"u}ller},
  journal={Current opinion in nephrology and hypertension},
  year={2001},
  volume={10 3},
  pages={315-20}
}
Tubulointerstitial fibrosis invariably accompanies the course of chronic renal failure towards end-stage renal disease. Tubular epithelial cells, the predominant cell type in the tubulointerstitium, are increasingly being recognized for playing a dominant role as mediators of renal fibrogenesis. Tubular epithelial cells become activated either by the glomerular ultrafiltrate from their apical side or by mononuclear cells from their basolateral side. They initiate the scarring process by… CONTINUE READING

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